Journal article

Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook

Nicolas Legrand, Alexander Ploss, Rudi Balling, Pablo D Becker, Chiara Borsotti, Nicolas Brezillon, Jennifer Debarry, Ype de Jong, Hongkui Deng, James P Di Santo, Stephanie Eisenbarth, Elizabeth Eynon, Richard A Flavell, Carlos A Guzman, Nicholas D Huntington, Dina Kremsdorf, Michael P Manns, Markus G Manz, Jean-Jacques Mention, Michael Ott Show all

CELL HOST & MICROBE | CELL PRESS | Published : 2009

Abstract

Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.