Journal article
Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook
Nicolas Legrand, Alexander Ploss, Rudi Balling, Pablo D Becker, Chiara Borsotti, Nicolas Brezillon, Jennifer Debarry, Ype de Jong, Hongkui Deng, James P Di Santo, Stephanie Eisenbarth, Elizabeth Eynon, Richard A Flavell, Carlos A Guzman, Nicholas D Huntington, Dina Kremsdorf, Michael P Manns, Markus G Manz, Jean-Jacques Mention, Michael Ott Show all
CELL HOST & MICROBE | CELL PRESS | Published : 2009
Abstract
Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.
Grants
Awarded by NCATS NIH HHS
Awarded by NHLBI NIH HHS
Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE