Journal article
Photocontrolled Cargo Release from Dual Cross-Linked Polymer Particles
S Tan, J Cui, Q Fu, E Nam, K Ladewig, JM Ren, EHH Wong, F Caruso, A Blencowe, GG Qiao
ACS Applied Materials and Interfaces | AMER CHEMICAL SOC | Published : 2016
Abstract
Burst release of a payload from polymeric particles upon photoirradiation was engineered by altering the cross-linking density. This was achieved via a dual cross-linking concept whereby noncovalent cross-linking was provided by cyclodextrin host-guest interactions, and irreversible covalent cross-linking was mediated by continuous assembly of polymers (CAP). The dual cross-linked particles (DCPs) were efficiently infiltrated (∼80-93%) by the biomacromolecule dextran (molecular weight up to 500 kDa) to provide high loadings (70-75%). Upon short exposure (5 s) to UV light, the noncovalent cross-links were disrupted resulting in increased permeability and burst release of the cargo (50 mol % w..
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Awarded by Australian Research Council