Journal article
New target regions for human hypertension via comparative genomics
M Stoll, AE Kwitek-Black, AW Cowley, EL Harris, SB Harrap, JE Krieger, MP Printz, AP Provoost, J Sassard, HJ Jacob
GENOME RESEARCH | COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT | Published : 2000
DOI: 10.1101/gr.10.4.473
Abstract
Models of human disease have long been used to understand the basic pathophysiology of disease and to facilitate the discovery of new therapeutics. However, as long as models have been used there have been debates about the utility of these models and their ability to mimic clinical disease at the phenotypic level. The application of genetic studies to both humans and model systems allows for a new paradigm, whereby a novel comparative genomics strategy combined with phenotypic correlates can be used to bridge between clinical relevance and model utility. This study presents a comparative genomic map for "candidate hypertension loci in humans" based on translating QTLs between rat and human,..
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Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
Awarded by NHLBI NIH HHS