Journal article

Genetic linkage of beta and gamma subunits of epithelial sodium channel to systolic blood pressure

ZYH Wong, M Stebbing, JA Ellis, A Lamantia, SB Harrap

LANCET | LANCET LTD | Published : 1999


BACKGROUND: Mutations in the genes on chromosome 16p12 that encode the beta and gamma subunits of the epithelial sodium channel (SCNNIB and SCNNIG, respectively) have been linked with rare sodium-dependent forms of low and high blood pressure. Other DNA variants in or around these genes may contribute to variation in blood pressure and the risk of coronary heart disease and stroke. METHODS: We studied 286 white families from the general population in Victoria, Australia. Each family comprised both parents and two natural children. All participants were genotyped at chromosome 16p12 by use of four highly polymorphic microsatellite markers. Quantitative phenotype measurements were correlated w..

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University of Melbourne Researchers