Journal article
Renal mechanisms of association between fibroblast growth factor 1 and blood pressure
M Tomaszewski, J Eales, M Denniff, S Myers, GS Chew, CP Nelson, P Christofidou, A Desai, C Büsst, L Wojnar, K Musialik, J Jozwiak, R Debiec, AF Dominiczak, G Navis, WH Van Gilst, P Van Der Harst, NJ Samani, S Harrap, P Bogdanski Show all
Journal of the American Society of Nephrology | Published : 2015
Abstract
The fibroblast growth factor 1 (FGF1) gene is expressed primarily in the kidney andmay contribute to hypertension. However, thebiologicmechanismsunderlying theassociationbetweenFGF1andBPregulation remain unknown.We report that the major allele of FGF1 single nucleotide polymorphism rs152524 was associated in a dose-dependent manner with systolic BP (P=9.65×10-5) and diastolic BP (P=7.61×10-3) in a meta-analysis of 14,364 individuals and with renal expression of FGF1 mRNA in 126 human kidneys (P=9.0×10-3). Next-generation RNA sequencing revealed that upregulated renal expression of FGF1 or of each of the three FGF1 mRNA isoforms individually was associated with higher BP. FGF1-stratified coex..
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Awarded by British Heart Foundation
Funding Acknowledgements
This work was supported by grants from the National Health & Medical Research Council of Australia, the Federation University Australia 'Self-sustaining Regions Research and Innovation Initiative', an Australian Government Collaborative Research Network grant (to F.J.C.) and British Heart Foundation (PG/12/9/29376 to M.T. and J.E.). AFD was a holder of a British Heart Foundation Chair in Cardiovascular Medicine. NJS holds a British Heart Foundation Chair in Cardiology and is an NIHR Senior Investigator. This work is part of the portfolio of research supported by NIHR Leicester Biomedical Research Unit in Cardiovascular Disease.