Journal article

Absence of genetic linkage of chromosome 5q31 with asthma and atopy in the general population

A Kamitani, ZYH Wong, P Dickson, L vanHerwerden, J Raven, AB Forbes, MJ Abramson, EH Walters, SB Harrap

THORAX | BRITISH MED JOURNAL PUBL GROUP | Published : 1997

Abstract

BACKGROUND: Clinical asthma is associated with increased serum total immunoglobulin E (IgE), atopy (skin prick test positivity to common aeroallergens), and bronchial hyperreactivity (BHR) to non-specific stimuli (positive methacholine challenge test). A region on chromosome 5q31-33 has been linked with increased total serum IgE and BHR. A study of the genetic linkage of this region with clinical asthma and atopy was therefore undertaken. METHODS: A polymorphic microsatellite marker in chromosome 5q31 (D5S399) was studied in 119 sibling pairs recruited from the general population who shared asthma, atopy, and/or BHR. Based on our population distribution of 13 different alleles, it was expect..

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