Conference Proceedings

A DEVELOPMENTAL GENETIC MECHANISM INVOLVING ANGIOTENSIN IN SPONTANEOUSLY HYPERTENSIVE RATS

SB HARRAP

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | BLACKWELL SCIENCE | Published : 1992

Abstract

1. Certain genes drive the blood pressure of young spontaneously hypertensive rats (SHR) to stable hypertensive levels in adulthood. 2. Relatively brief blockade of the renin-angiotensin system in young SHR can reset the track of SHR pressure to a lower level for the life of the animal. This effect appears to be a characteristic of the SHR strain. 3. It is proposed that the expression of a particular SHR hypertensive gene depends on angiotensin and is limited to young animals. This hypothesis explains some of the phenotypic abnormalities observed in young SHR and the decremental long-term blood pressure effects following ACE inhibitor treatment. 4. The identity of the gene is unclear, but in..

View full abstract

University of Melbourne Researchers