Journal article

iSRAP - a one-touch research tool for rapid profiling of small RNA-seq data

Camelia Quek, Chol-hee Jung, Shayne A Bellingham, Andrew Lonie, Andrew F Hill

JOURNAL OF EXTRACELLULAR VESICLES | TAYLOR & FRANCIS LTD | Published : 2015

Abstract

Small non-coding RNAs have been significantly recognized as the key modulators in many biological processes, and are emerging as promising biomarkers for several diseases. These RNA species are transcribed in cells and can be packaged in extracellular vesicles, which are small vesicles released from many biotypes, and are involved in intercellular communication. Currently, the advent of next-generation sequencing (NGS) technology for high-throughput profiling has further advanced the biological insights of non-coding RNA on a genome-wide scale and has become the preferred approach for the discovery and quantification of non-coding RNA species. Despite the routine practice of NGS, the process..

View full abstract

Grants

Awarded by Australian Research Council


Awarded by National Health and Medical Research Council


Funding Acknowledgements

We thank the Life Sciences Computation Centre of Victorian Life Sciences Computation Initiative, an initiative of the Victorian Government, Australia, hosted at the University of Melbourne, for high-performance computing system and resources. This work was supported by the Australian Research Council (FT100100560 to AFH) and the National Health and Medical Research Council (628946 to AFH). CQ was supported by Melbourne International Research Scholarship.