Journal article
Quantitative and qualitative analysis of [18F]FDG and [18F]FAZA positron emission tomography of head and neck cancers and associations with HPV status and treatment outcome
EE Graves, RJ Hicks, D Binns, M Bressel, QT Le, L Peters, RJ Young, D Rischin
European Journal of Nuclear Medicine and Molecular Imaging | Published : 2016
Abstract
Purpose: While methods for imaging tumor hypoxia with positron emission tomography (PET) have been developed, optimal methods for interpreting and utilizing these datasets in the clinic remain unclear. In this study, we analyzed hypoxia PET images of head and neck cancer patients and compared imaging metrics with human papilloma virus (HPV) status and clinical outcome. Methods: Forty-one patients treated as part of a phase III trial of the hypoxic cytotoxin tirapazamine (TROG 02.02) were imaged with PET using fluorodeoxyglucose (FDG) and fluoroazomycin arabinoside (FAZA). FDG and FAZA PET images were interpreted qualitatively and quantitatively, and compared with tumor T stage, HPV status, a..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was funded by the National Institutes of Health and the National Cancer Institute of the United States (R01 CA118582, P01 CA67166) and by the National Health and Medical Research Council of Australia.