Antiglucocorticoids and related treatments for psychosis
S Hetrick, C Garner, L Phillips, S Bendall
Cochrane Database of Systematic Reviews | Cochrane Collaboration | Published : 2016
BACKGROUND: Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been implicated in the development and relapse of psychotic disorders. Elevated cortisol secretion has been positively linked with symptom severity in people with psychosis. Antiglucocorticoid and related drugs that target the HPA axis may be useful for the treatment of individuals with psychosis. OBJECTIVES: 1. To determine the effects of antiglucocorticoid and related drugs for the treatment of psychosis, when used alone or in combination with antipsychotic medication.2. To determine whether the effects of these medications differs between those in a prodromal phase or first episode of psychosis, and those with more es..View full abstract
Internal sourcesORYGEN Research Centre, University of Melbourne, Australia.