Journal article

High Conservation Level of CD8( ) T Cell Immunogenic Regions Within an Unusual H1N2 Human Influenza Variant

Naomi Komadina, Sergio M Quinones-Parra, Katherine Kedzierska, James M McCaw, Anne Kelso, Karin Leder, Jodie McVernon

JOURNAL OF MEDICAL VIROLOGY | WILEY | Published : 2016

Abstract

Current seasonal influenza vaccines require regular updates due to antigenic drift causing loss of effectiveness and therefore providing little or no protection against novel influenza A subtypes. Next generation vaccines capable of eliciting CD8(+) T cell (CTL) mediated cross-protective immunity may offer a long-term alternative strategy. However, measuring pre- and existing levels of CTL cross-protection in humans is confounded by differences in infection histories across individuals. During 2000-2003, H1N2 viruses circulated persistently in the human population for the first time and we hypothesized that the viral nucleoprotein (NP) contained novel CTL epitopes that may have contributed t..

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Grants

Awarded by NHMRC


Awarded by ARC Future Fellowship


Funding Acknowledgements

Grant sponsor: The Melbourne WHO Collaborating Centre for Reference and Research is supported by the Australian Government Department of Health; Grant sponsor: University of Melbourne International Research Scholarship; Grant sponsor: NHMRC Career Development Fellow (CDF) 2; Grant number: AI023294; Grant sponsor: NHMRC Career Development Fellowship; Grant number: APP1061321; Grant sponsor: ARC Future Fellowship; Grant number: FT110100250