Journal article
Altered posterior cingulate brain metabolites and cognitive dysfunction in preterm adolescents
JLY Cheong, A Bainbridge, PJ Anderson, KJ Lee, AC Burnett, DK Thompson, G Roberts, SJ Wood, LW Doyle, NJ Robertson
Pediatric Research | NATURE PUBLISHING GROUP | Published : 2016
DOI: 10.1038/pr.2015.272
Abstract
Extremely preterm (EP, <28 wk gestation) individuals have increased the risk of cognitive deficits compared with controls. The posterior cingulate region has an important role in cognitive function, but how this is affected by preterm birth is unknown. We aimed to compare brain metabolite ratios of neurons and cell membranes between EP 18-y olds and controls, and explore the association between metabolite ratios and cognitive outcomes.Method:A regional cohort of 150 EP and 134 controls were recruited for the study. Cerebral metabolites were measured using proton magnetic resonance spectroscopy (MRS) obtained from a left posterior cingulate voxel. Total N-acetylaspartate (tNAA, neuronal marke..
View full abstractGrants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by the Australian National Health and Medical Research Council (Project Grant ID 491246 to L.D., P.A., S.W., J.C., as well as C Robertson, S Hope, and D Hacking; Centre of Clinical Research Excellence Grant ID 546519; Senior Research Fellowship ID 628371 to P.A.; Early Career Fellowship ID 1053787 to J.C.; Early Career Fellowship ID 1012236 to D.T.; Career Development Fellowship ID 1053609 to K.J.L.), the UK Department of Health's NIHR Biomedical Research Centres funding scheme to AB, and the Victorian Government Operational Infrastructure Support Program. The authors declare no conflict of interest.