Journal article
Outcomes of two trials of oxygen-saturation targets in preterm infants
W Tarnow-Mordi, B Stenson, A Kirby, E Juszczak, M Donoghoe, S Deshpande, C Morley, A King, LW Doyle, BW Fleck, PG Davis, HL Halliday, W Hague, P Cairns, BA Darlow, AR Fielder, V Gebski, N Marlow, K Simmer, W Tin Show all
New England Journal of Medicine | MASSACHUSETTS MEDICAL SOC | Published : 2016
Abstract
BACKGROUND The safest ranges of oxygen saturation in preterm infants have been the subject of debate. METHODS In two trials, conducted in Australia and the United Kingdom, infants born before 28 weeks' gestation were randomly assigned to either a lower (85 to 89%) or a higher (91 to 95%) oxygen-saturation range. During enrollment, the oximeters were revised to correct a calibration-algorithm artifact. The primary outcome was death or disability at a corrected gestational age of 2 years; this outcome was evaluated among infants whose oxygen saturation was measured with any study oximeter in the Australian trial and those whose oxygen saturation was measured with a revised oximeter in the U.K...
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Awarded by Medical Research Council
Funding Acknowledgements
Funded by the Australian National Health and Medical Research Council and others; BOOST-II Current Controlled Trials number, ISRCTN00842661, and Australian New Zealand Clinical Trials Registry number, ACTRN12605000055606.