Journal article

Outcomes of Two Trials of Oxygen-Saturation Targets in Preterm Infants

William Tarnow-Mordi, Ben Stenson, Adrienne Kirby, Edmund Juszczak, Mark Donoghoe, Sanjeev Deshpande, Colin Morley, Andrew King, Lex W Doyle, Brian W Fleck, Peter G Davis, Henry L Halliday, Wendy Hague, Pamela Cairns, Brian A Darlow, Alistair R Fielder, Val Gebski, Neil Marlow, Karen Simmer, Win Tin Show all

NEW ENGLAND JOURNAL OF MEDICINE | MASSACHUSETTS MEDICAL SOC | Published : 2016

Abstract

BACKGROUND: The safest ranges of oxygen saturation in preterm infants have been the subject of debate. METHODS: In two trials, conducted in Australia and the United Kingdom, infants born before 28 weeks' gestation were randomly assigned to either a lower (85 to 89%) or a higher (91 to 95%) oxygen-saturation range. During enrollment, the oximeters were revised to correct a calibration-algorithm artifact. The primary outcome was death or disability at a corrected gestational age of 2 years; this outcome was evaluated among infants whose oxygen saturation was measured with any study oximeter in the Australian trial and those whose oxygen saturation was measured with a revised oximeter in the U...

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