Journal article

Impact of Placental Malaria and Hypergammaglobulinemia on Transplacental Transfer of Respiratory Syncytial Virus Antibody in Papua New Guinea

Jessica E Atwell, Bhagvanji Thumar, Leanne J Robinson, Roselyn Tobby, Phantica Yambo, Maria Ome-Kaius, Peter M Siba, Holger W Unger, Stephen J Rogerson, Christopher L King, Ruth A Karron

The Journal of Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2016

Abstract

BACKGROUND: Passively acquired respiratory syncytial virus (RSV) neutralizing antibody protects against RSV-associated lower respiratory infections, but placental malaria (PM) and maternal hypergammaglobulinemia might interfere with transplacental immunoglobulin transport. METHODS: We measured RSV plaque-reduction neutralization (PRN) antibody in 300 full-term maternal/cord serum pairs in 2 cohorts in malaria-endemic Papua New Guinea: Alexishafen (2005-2008) and the Fetal Immunity Study (FIS) (2011-2013). We defined impaired transport as a cord-to-maternal titer ratio <1.0 and a protective RSV PRN titer (PRNT) ≥1:200. RESULTS: PM and hypergammaglobulinemia occurred in 60% and 54% of Alexisha..

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