Impact of Placental Malaria and Hypergammaglobulinemia on Transplacental Transfer of Respiratory Syncytial Virus Antibody in Papua New Guinea
Jessica E Atwell, Bhagvanji Thumar, Leanne J Robinson, Roselyn Tobby, Phantica Yambo, Maria Ome-Kaius, Peter M Siba, Holger W Unger, Stephen J Rogerson, Christopher L King, Ruth A Karron
The Journal of Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2016
BACKGROUND: Passively acquired respiratory syncytial virus (RSV) neutralizing antibody protects against RSV-associated lower respiratory infections, but placental malaria (PM) and maternal hypergammaglobulinemia might interfere with transplacental immunoglobulin transport. METHODS: We measured RSV plaque-reduction neutralization (PRN) antibody in 300 full-term maternal/cord serum pairs in 2 cohorts in malaria-endemic Papua New Guinea: Alexishafen (2005-2008) and the Fetal Immunity Study (FIS) (2011-2013). We defined impaired transport as a cord-to-maternal titer ratio <1.0 and a protective RSV PRN titer (PRNT) ≥1:200. RESULTS: PM and hypergammaglobulinemia occurred in 60% and 54% of Alexisha..View full abstract
Awarded by National Institute of Allergy and Infectious Diseases at the National Institutes of Health (NIH)
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
This work was supported by PATH as well as the National Institute of Allergy and Infectious Diseases at the National Institutes of Health (NIH) (AI AI064687 and DMID #11-0037).