Delayed astrocytic contact with cerebral blood vessels in FGF-2 deficient mice does not compromise permeability properties at the developing blood-brain barrier
Norman R Saunders, Katarzyna M Dziegielewska, Klaus Unsicker, C Joakim Ek
DEVELOPMENTAL NEUROBIOLOGY | WILEY | Published : 2016
The brain functions within a specialized environment tightly controlled by brain barrier mechanisms. Understanding the regulation of barrier formation is important for understanding brain development and may also lead to finding new ways to deliver pharmacotherapies to the brain; access of many potentially promising drugs is severely hindered by these barrier mechanisms. The cellular composition of the neurovascular unit of the blood-brain barrier proper and their effects on regulation of its function are beginning to be understood. One hallmark of the neurovascular unit in the adult is the astroglial foot processes that tightly surround cerebral blood vessels. However their role in barrier ..View full abstract
Awarded by European Union
Contract grant sponsor: Wilhelm and Martina Lundgren Foundation and European Union Grant FP7; contract grant number: HEALTH-F2-2009-241778.Contract grant sponsor: Magnus Bergwall Foundation and Ake Wiberg Foundation.