Journal article
SaMpling Antibiotics in Renal Replacement Therapy (SMARRT): An observational pharmacokinetic study in critically ill patients
JA Roberts, GYS Choi, GM Joynt, SK Paul, R Deans, S Peake, L Cole, D Stephens, R Bellomo, J Turnidge, SC Wallis, MS Roberts, DM Roberts, M Lassig-Smith, T Starr, J Lipman
BMC Infectious Diseases | Published : 2016
Abstract
Background: Optimal antibiotic dosing is key to maximising patient survival, and minimising the emergence of bacterial resistance. Evidence-based antibiotic dosing guidelines for critically ill patients receiving RRT are currently not available, as RRT techniques and settings vary greatly between ICUs and even individual patients. We aim to develop a robust, evidence-based antibiotic dosing guideline for critically ill patients receiving various forms of RRT. We further aim to observe whether therapeutic antibiotic concentrations are associated with reduced 28-day mortality. Methods/Design: We designed a multi-national, observational pharmacokinetic study in critically ill patients requiring..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The study is funded by the Australian National Health and Medical Research Council (APP1026424) and partially supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region, China (Project No.: CUHK 14106614).