Journal article

Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy

Monica Rolando, Pedro Escoll, Tamara Nora, Joelle Botti, Valarie Boitez, Carmen Bedia, Craig Daniels, Gilu Abraham, Peter J Stogios, Tatiana Skarina, Charlotte Christophe, Delphine Dervins-Ravault, Christel Cazalet, Hubert Hilbi, Thusitha WT Rupasinghe, Dedreia Tull, Malcolm J McConville, Sze Ying Ong, Elizabeth L Hartland, Patrice Codogno Show all

Proceedings of the National Academy of Sciences | NATL ACAD SCIENCES | Published : 2016

Grants

Awarded by Conseil de la Region Ile-de-France, Fondation pour la Recherche Medicale


Awarded by Institut Pasteur, Domaine d'Interet Majeur Malinf Grant


Awarded by Infect-European Research Area (ERA) project EUGENPATH


Awarded by Fondation pour la Recherche Medicale (FRM) Grant


Awarded by Swiss National Science Foundation


Awarded by Bundesministerium fur Bildung und Forschung (Infect-ERA project EUGENPATH)


Awarded by National Institutes of Health


Awarded by US Department of Energy, Office of Biological and Environmental Research


Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES


Funding Acknowledgements

We thank G. Pfaffinger for D. discoideum infection, L. Eichinger for ATG9<SUP>-/-</SUP> D. discoideum, and the Imagopole-CiTech (part of the FranceBioImaging infrastructure supported by ANR-10-INSB-04-01, Conseil de la Region Ile-de-France, Fondation pour la Recherche Medicale). C. Buchrieser was funded by the Institut Pasteur, Domaine d'Interet Majeur Malinf Grant ANR-10-LABX-62-IBEID, and Infect-European Research Area (ERA) project EUGENPATH (ANR-13-IFEC-0003-02); P.E. was funded by Fondation pour la Recherche Medicale (FRM) Grant DEQ20120323697; C. Bedia was funded by a fellowship from Agencia de Gestio d'Ajuts Universitaris i Recerca, Generalitat de Catalunya; H.H. was funded by the University of Zurich, the Swiss National Science Foundation (31003A_153200), and the Bundesministerium fur Bildung und Forschung (Infect-ERA project EUGENPATH, 031A410A). The crystal structure was solved in part by National Institutes of Health Grants GM074942 and GM094585 (to A.S. through Midwest Center for Structural Genomics) and by the US Department of Energy, Office of Biological and Environmental Research, under Contract DE-AC02-06CH11357. The P.C. and T.L. laboratories were supported by INSERM.