Journal article

Elevated baseline glomerular filtration rate (GFR) is independently associated with a more rapid decline in renal function of patients with type 1 diabetes

Hilary J Thomson, Elif I Ekinci, Nicholas J Radcliffe, Jas-mine Seah, Richard J MacIsaac, George Jerums, Erosha Premaratne

JOURNAL OF DIABETES AND ITS COMPLICATIONS | ELSEVIER SCIENCE INC | Published : 2016

Abstract

AIMS: Renal hyperfiltration is observed prior to the development of diabetic kidney disease (DKD) in patients with type 1 diabetes (T1DM); however its significance remains uncertain. Longitudinal data were used to investigate the association between measured baseline glomerular filtration rate (GFR) and renal function decline in patients with T1DM. METHODS: This study included 142 adult patients with T1DM and ≥2 measurements of glomerular filtration rate (mGFR; determined by diethylene-triamine-penta-acetic acid plasma clearance). Median follow up was 19 years. Patients were stratified by baseline mGFR quartile. The relationship between baseline mGFR and rate of renal function decline was as..

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