Journal article

Diffuse Ventricular Fibrosis on Cardiac Magnetic Resonance Imaging Associates With Ventricular Tachycardia in Patients With Hypertrophic Cardiomyopathy

Alex JA McLellan, Andris H Ellims, Sandeep Prabhu, Alex Voskoboinik, Leah M Iles, James L Hare, David M Kaye, Ivan Macciocca, Justin A Mariani, Jonathan M Kalman, Andrew J Taylor, Peter M Kistler

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY | WILEY-BLACKWELL | Published : 2016

Abstract

INTRODUCTION: Non-sustained ventricular tachycardia (NSVT) is a risk factor for sudden cardiac death (SCD) in patients with hypertrophic cardiomyopathy (HCM). We aimed to assess whether diffuse ventricular fibrosis on cardiac magnetic resonance (CMR) imaging could be a surrogate marker for ventricular arrhythmias in patients with HCM. METHODS: A total of 100 patients with HCM (mean age 51 ± 13 years, septal wall thickness 20 ± 5 mm) underwent CMR with a 1.5 T scanner to determine the presence of ventricular late gadolinium enhancement (LGE) for focal fibrosis, and post-contrast T1 mapping for diffuse ventricular fibrosis. The presence of NSVT was determined by Holter monitoring and a subset ..

View full abstract

Grants

Funding Acknowledgements

Drs. McLellan, Prabhu, Voskoboinik, and Ellims are supported by co-funded Australian National Health and Medical Research Council (NHMRC)/Australian National Heart Foundation (NHF) Postgraduate Scholarships and BakerIDI Bright Sparks Scholarships. Dr. Iles is supported by an NHMRC/NHF early career fellowship. A/Professor Taylor is supported by an NHMRC project grant. Professors Kistler and Kalman are supported by practitioner fellowships from the NHMRC. This research is supported in part by the Victorian Government's Operational Infrastructure Funding.