Journal article
Novel mechanisms in the pathogenesis of atrial fibrillation: Practical applications
DH Lau, U Schotten, R Mahajan, NA Antic, SN Hatem, RK Pathak, JML Hendriks, JM Kalman, P Sanders
European Heart Journal | OXFORD UNIV PRESS | Published : 2016
Abstract
Intensive research over the last few decades has seen significant advances in our understanding of the complex mechanisms underlying atrial fibrillation (AF). The epidemic of AF and related hospitalizations has been described as a 'rising tide' with estimates of the global AF burden showing no sign of retreat. There is urgency for effective translational programs in this field to facilitate more individualized and targeted therapy to modify the abnormal atrial substrate responsible for the perpetuation of this arrhythmia. In this review, we chose to focus on several novel aspects of AF pathogenesis whereby practical applications in clinical practice are currently available or potentially not..
View full abstractGrants
Awarded by European Union
Awarded by French National Agency
Awarded by European Union (FP7 large collaborative project EUTRAF)
Awarded by Netherlands Heart Foundation (CVON grant)
Funding Acknowledgements
D.H.L. is supported by a postdoctoral fellowship from the National Health and Medical Research Council of Australia (NHMRC). R.M. is supported by the Leo J. Mahar Lectureship from the University of Adelaide. R.K.P. is supported by a postgraduate scholarship from the Lion's Medical Research Foundation, and an Australian Postgraduate Award and the Leo J. Mahar Electrophysiology Scholarships from the University of Adelaide. S.N.H. is supported by the Fondation Leducq 'Structural Alterations in the Myocardium and the Substrate for Cardiac Fibrillation', the European Union (EUTRAF-261057), the French National Agency (ANR-10-IAHU-05), and the 'Fondation de France'. J.H. is supported by the Derek Frewin Lectureship from the University of Adelaide. J.M.K. and P.S. are supported by Practitioner Fellowships from the NHMRC. This work was partly supported by a grant from the European Union (FP7 large collaborative project EUTRAF, No. 261057 to U.S.) and by a grant from the Netherlands Heart Foundation (CVON grant 2014-09, RACE V).