Insights into the naturally acquired immune response to Plasmodium vivax malaria
Rhea J Longley, Jetsumon Sattabongkot, Ivo Mueller
PARASITOLOGY | CAMBRIDGE UNIV PRESS | Published : 2016
Plasmodium vivax is the most geographically widespread of the malaria parasites causing human disease, yet it is comparatively understudied compared with Plasmodium falciparum. In this article we review what is known about naturally acquired immunity to P. vivax, and importantly, how this differs to that acquired against P. falciparum. Immunity to clinical P. vivax infection is acquired more quickly than to P. falciparum, and evidence suggests humans in endemic areas also have a greater capacity to mount a successful immunological memory response to this pathogen. Both of these factors give promise to the idea of a successful P. vivax vaccine. We review what is known about both the cellular ..View full abstract
Awarded by National Institute of Allergy and Infectious Diseases, USA (NIH)
Awarded by NHMRC
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
We acknowledge the financial support from the National Institute of Allergy and Infectious Diseases, USA (NIH grant number 5R01 AI 104822) and the Foundation for Innovative New Diagnostics. IM is supported by a NHMRC Senior Research Fellowship (#1043345).