Harnessing the secretome of cardiac stem cells as therapy for ischemic heart disease
Ramin Khanabdali, Ayeshah A Rosdah, Gregory J Dusting, Shiang Y Lim
BIOCHEMICAL PHARMACOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2016
Adult stem cells continue to promise opportunities to repair damaged cardiac tissue. However, precisely how adult stem cells accomplish cardiac repair, especially after ischemic damage, remains controversial. It has been postulated that the clinical benefit of adult stem cells for cardiovascular disease results from the release of cytokines and growth factors by the transplanted cells. Studies in animal models of myocardial infarction have reported that such paracrine factors released from transplanted adult stem cells contribute to improved cardiac function by several processes. These include promoting neovascularization of damaged tissue, reducing inflammation, reducing fibrosis and scar f..View full abstract
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Awarded by National Health and Medical Research Council of Australia
These studies were supported by grants from the National Health and Medical Research Council of Australia (NHMRC APP1024817), CASS Foundation, St. Vincent's Hospital (Melbourne) Research Endowment Fund, and Stafford Fox Medical Foundation. G.J.D. is a Principal Research Fellow of the NHMRC. The O'Brien Institute Department, St Vincent's Institute of Medical Research, and the Centre for Eye Research Australia receive Operational Infrastructure Support from the Victorian State Government.