Modulating Astrocyte Transition after Stroke to Promote Brain Rescue and Functional Recovery: Emerging Targets Include Rho Kinase
Hima Charika S Abeysinghe, Ellie L Phillips, Heung Chin-Cheng, Philip M Beart, Carli L Roulston
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | MDPI | Published : 2016
Stroke is a common and serious condition, with few therapies. Whilst previous focus has been directed towards biochemical events within neurons, none have successfully prevented the progression of injury that occurs in the acute phase. New targeted treatments that promote recovery after stroke might be a better strategy and are desperately needed for the majority of stroke survivors. Cells comprising the neurovascular unit, including blood vessels and astrocytes, present an alternative target for supporting brain rescue and recovery in the late phase of stroke, since alteration in the unit also occurs in regions outside of the lesion. One of the major changes in the unit involves extensive m..View full abstract
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Awarded by National Health and Medical Research Council Research Fellowship
This study was supported in part by grants from the Brain Foundation Australia and the St Vincent's Hospital Research Endowment Fund; Professor PM Beart is supported by a National Health and Medical Research Council Research Fellowship (APP1019833). The Florey Institute of Neuroscience and Mental Health receive infrastructure support from the Victorian State Government (Australia). The funders had no role in the decision to publish, or preparation of the manuscript.