Journal article

Subjective memory decline predicts greater rates of clinical progression in preclinical Alzheimer's disease

Rachel F Buckley, Paul Maruff, David Ames, Pierrick Bourgeat, Ralph N Martins, Colin L Masters, Stephanie Rainey-Smith, Nicola Lautenschlager, Christopher C Rowe, Greg Savage, Victor L Villemagne, Kathryn A Ellis

Alzheimers & Dementia | ELSEVIER SCIENCE INC | Published : 2016


INTRODUCTION: The objective of this study was to determine the utility of subjective memory decline (SMD) to predict episodic memory change and rates of clinical progression in cognitively normal older adults with evidence of high β-amyloid burden (CN Aβ+). METHODS: Fifty-eight CN Aβ+ participants from the Australian Imaging, Biomarkers, and Lifestyle study responded to an SMD questionnaire and underwent comprehensive neuropsychological assessments. Participant data for three follow-up assessments were analyzed. RESULTS: In CN Aβ+, subjects with high SMD did not exhibit significantly greater episodic memory decline than those with low SMD. High SMD was related to greater rates of progression..

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Funding Acknowledgements

The authors thank all the participants who took part in this study and the clinicians who referred MCI participants to the study. They thank Dr Yen Ying Lim for providing statistical consultation for the linear mixed modeling analyses and Dr S. Lance Macaulay for editing the article. The AIBL study ( received support from Commonwealth Scientific and Industrial Research Organisation, the Science and Industry Endowment Fund (, National Health and Medical Research Council, and Dementia Collaborative Research Centres.