Journal article
Anxiety, depression and fatigue at 5-year review following CNS demyelination
S Simpson, H Tan, P Otahal, BV Taylor, AL Ponsonby, RM Lucas, L Blizzard, PC Valery, J Lechner-Scott, C Shaw, D Williams, I van der Mei, K Dear, T Dwyer, S Broadley, T Kilpatrick, C Chapman, A Coulthard
Acta Neurologica Scandinavica | WILEY-BLACKWELL | Published : 2016
DOI: 10.1111/ane.12554
Abstract
Background: Anxiety and depression are common in multiple sclerosis (MS). We evaluated the prevalence and factors associated with anxiety, depression and fatigue at the 5-year review of a longitudinal cohort study following a first clinical diagnosis of CNS demyelination (FCD). Methods: Cases with a FCD were recruited soon after diagnosis and followed annually thereafter. A variety of environmental, behavioural and clinical covariates were measured at five-year review. Anxiety and depression were measured using the Hospital Anxiety & Depression Scale (HADS), and fatigue by the Fatigue Severity Scale (FSS). Results: Of the 236 cases, 40.2% had clinical anxiety (median HADS-A: 6.0), 16.0% had ..
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Awarded by National Multiple Sclerosis Society
Funding Acknowledgements
The Ausimmune and AusLong Studies were funded by the National Multiple Sclerosis Society of the United States of America (award RG3364A1/2) and the National Health and Medical Research Council of Australia (APP316901 and 224215).SSJ is supported by an MS Research Australia Postdoctoral Research Fellowship.PCV was supported by the Australian National Health and Medical Research Council (Career Development Fellowship #1083090).IvdM is supported by an Australian Research Council Future Fellowship.