Apocynin and ebselen reduce influenza A virus-induced lung inflammation in cigarette smoke-exposed mice
LC Oostwoud, P Gunasinghe, HJ Seow, JM Ye, S Selemidis, S Bozinovski, R Vlahos
SCIENTIFIC REPORTS | NATURE RESEARCH | Published : 2016
Influenza A virus (IAV) infections are a common cause of acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Oxidative stress is increased in COPD, IAV-induced lung inflammation and AECOPD. Therefore, we investigated whether targeting oxidative stress with the Nox2 oxidase inhibitors and ROS scavengers, apocynin and ebselen could ameliorate lung inflammation in a mouse model of AECOPD. Male BALB/c mice were exposed to cigarette smoke (CS) generated from 9 cigarettes per day for 4 days. On day 5, mice were infected with 1 × 10(4.5) PFUs of the IAV Mem71 (H3N1). BALF inflammation, viral titers, superoxide production and whole lung cytokine, chemokine and protease mRNA expres..View full abstract
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Awarded by National Health and Medical Research Council of Australia
Awarded by Australian Research Council
This study was supported by the National Health and Medical Research Council of Australia [Project Grants 1027112 and 1084627] and the Australian Research Council [Future Fellowship FT120100876].