Identification of ABCC8 as a contributory gene to impaired early-phase insulin secretion in NZO mice
Sofianos Andrikopoulos, Barbara C Fam, Anita Holdsworth, Sherley Visinoni, Zheng Ruan, Maria Stathopoulos, Anne W Thorburn, Christos N Joannides, Michael Cancilla, Lois Balmer, Joseph Proietto, Grant Morahan
JOURNAL OF ENDOCRINOLOGY | BIOSCIENTIFICA LTD | Published : 2016
Type 2 diabetes (T2D) is associated with defective insulin secretion, which in turn contributes to worsening glycaemic control and disease progression. The genetic cause(s) associated with impaired insulin secretion in T2D are not well elucidated. Here we used the polygenic New Zealand Obese (NZO) mouse model, which displays all the cardinal features of T2D including hyperglycaemia to identify genes associated with β-cell dysfunction. A genome-wide scan identified a major quantitative trait locus (QTL) on chromosome 7 associated with defective glucose-mediated insulin secretion. Using congenic strains, the locus was narrowed to two candidate genes encoding the components of the KATP channel:..View full abstract
Awarded by National Health and Medical Research Council of Australia
This work was supported by a project grant from the National Health and Medical Research Council of Australia and the National Heart Foundation. S A was supported by a Biomedical Career Development Award and Senior Research Fellowship from the National Health and Medical Research Council of Australia. L B and G M are supported by a Program grant from the National Health and Medical Research Council of Australia (516700) and by the Diabetes Research Foundation of W A (Inc).