Journal article

A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk

Ruth C Travis, Paul N Appleby, Richard M Martin, Jeff MP Holly, Demetrius Albanes, Amanda Black, H Bas Bueno-de-Mesquita, June M Chan, Chu Chen, Maria-Dolores Chirlaque, Michael B Cook, Melanie Deschasaux, Jenny L Donovan, Luigi Ferrucci, Pilar Galan, Graham G Giles, Edward L Giovannucci, Marc J Gunter, Laurel A Habel, Freddie C Hamdy Show all

CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2016

Abstract

The role of insulin-like growth factors (IGF) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3) and prostate cancer risk, we pooled individual participant data from 17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the ORs for prostate cancer based on the study-specific fifth of each analyte. Overall, IGF-I, IGF-II, IGFBP-2, and IGFBP-3 concentrations were positively associated with prostate cancer risk (Ptrend all ≤ 0.005), and IGFBP-1 was..

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