A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk

Ruth C Travis; Paul N Appleby; Richard M Martin; Jeff MP Holly; Demetrius Albanes; Amanda Black; H Bas Bueno-de-Mesquita; June M Chan; Chu Chen; Maria-Dolores Chirlaque; Michael B Cook; Melanie Deschasaux; Jenny L Donovan; Luigi Ferrucci; Pilar Galan; Graham G Giles; Edward L Giovannucci; Marc J Gunter; Laurel A Habel; Freddie C Hamdy; Kathy J Helzlsouer; Serge Hercberg; Robert N Hoover; Joseph AMJL Janssen; Rudolf Kaaks; Tatsuhiko Kubo; Loic Le Marchand; E Jeffrey Metter; Kazuya Mikami; Joan K Morris; David E Neal; Marian L Neuhouser; Kotaro Ozasa; Domenico Palli; Elizabeth A Platz; Michael N Pollak; Alison J Price; Monique J Roobol; Catherine Schaefer; Jeannette M Schenk; Gianluca Severi; Meir J Stampfer; Par Stattin; Akiko Tamakoshi; Catherine M Tangen; Mathilde Touvier; Nicholas J Wald; Noel S Weiss; Regina G Ziegler; Timothy J Key; Naomi E Allen

Journal article

A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk

Ruth C Travis, Paul N Appleby, Richard M Martin, Jeff MP Holly, Demetrius Albanes, Amanda Black, H Bas Bueno-de-Mesquita, June M Chan, Chu Chen, Maria-Dolores Chirlaque, Michael B Cook, Melanie Deschasaux, Jenny L Donovan, Luigi Ferrucci, Pilar Galan, Graham G Giles, Edward L Giovannucci, Marc J Gunter, Laurel A Habel, Freddie C Hamdy Show all

CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2016

DOI: 10.1158/0008-5472.CAN-15-1551

Abstract

The role of insulin-like growth factors (IGF) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3) and prostate cancer risk, we pooled individual participant data from 17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the ORs for prostate cancer based on the study-specific fifth of each analyte. Overall, IGF-I, IGF-II, IGFBP-2, and IGFBP-3 concentrations were positively associated with prostate cancer risk (Ptrend all ≤ 0.005), and IGFBP-1 was..

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