Journal article
Anomalous basal ganglia connectivity and obsessive– compulsive behaviour in patients with prader Willi syndrome
J Pujol, L Blanco-Hinojo, S Esteba-Castillo, A Caixàs, BJ Harrison, M Bueno, J Deus, M Rigla, D Macià, J Llorente-Onaindia, R Novell-Alsina
Journal of Psychiatry and Neuroscience | CMA-CANADIAN MEDICAL ASSOC | Published : 2016
DOI: 10.1503/jpn.140338
Abstract
Background: Prader Willi syndrome is a genetic disorder with a behavioural expression characterized by the presence of obsessive– compulsive phenomena ranging from elaborate obsessive eating behaviour to repetitive skin picking. Obsessive–compulsive disorder (OCD) has been recently associated with abnormal functional coupling between the frontal cortex and basal ganglia. We have tested the potential association of functional connectivity anomalies in basal ganglia circuits with obsessive–compulsive behaviour in patients with Prader Willi syndrome. Methods: We analyzed resting-state functional MRI in adult patients and healthy controls. Whole-brain functional connectivity maps were generated ..
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Grants
Awarded by Fondo de Investigacion Santiaria del Instituto Carlos III
Awarded by Fundacio Parc Tauli
Awarded by Research Funding Management of the Catalonia Government
Awarded by PFIS grant from the Fondo de Investigacion Santiaria del Instituto Carlos III
Awarded by National Health and Medical Research Council (NHMRC, Australia)
Funding Acknowledgements
This study was supported in part by the Fondo de Investigacion Santiaria del Instituto Carlos III (Grant PI-10/00940) and Fundacio Parc Tauli (Grants CIR 2010/006 and CIR 2011/004). The Agency of University and Research Funding Management of the Catalonia Government participated in the context of Research Group SGR2014-1673. L. Blanco-Hinojo was supported by the PFIS grant FI10/00387 from the Fondo de Investigacion Santiaria del Instituto Carlos III. Dr. B. Harrison was supported by a National Health and Medical Research Council (NHMRC, Australia) Clinical Career Development Fellowship (628509). We thank the Associacio Catalana de Sindrome de Prader-Willi, Fundacion Sindrome de Prader-Willi and all the patients and their families for agreeing to participate.