Adults with a history of illicit amphetamine use exhibit abnormal substantia nigra morphology and parkinsonism
Gabrielle Todd, Verity Pearson-Dennett, Robert A Wilcox, Minh T Chau, Kerry Thoirs, Dominic Thewlis, Adam P Vogel, Jason M White
PARKINSONISM & RELATED DISORDERS | ELSEVIER SCI LTD | Published : 2016
INTRODUCTION: The sonographic appearance of the substantia nigra is abnormally bright and enlarged (hyperechogenic) in young adults with a history of illicit stimulant use. The abnormality is a risk factor for Parkinson's disease. The aim of the current study was to identify the type of illicit stimulant drug associated with substantia nigra hyperechogenicity and to determine if individuals with a history of illicit stimulant use exhibit clinical signs of parkinsonism. We hypothesised that use of amphetamines (primarily methamphetamine) is associated with substantia nigra hyperechogenicity and clinical signs of parkinsonism. METHODS: The area of echogenic signal in the substantia nigra was m..View full abstract
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Awarded by Clive and Vera Ramaciotti Foundation
Awarded by National Health and Medical Research Council of Australia
The work was supported by the Clive and Vera Ramaciotti Foundation (Establishment Grant, ID 2974/2010), National Health and Medical Research Council of Australia (GT held a Career Development Award ID 627003, APV holds a Career Development Fellowship ID 1082910), Australian Government (VPD holds an Australian Postgraduate Award), and the University of South Australia. The funding sources had no involvement in the i) study design, ii) collection, analysis, and interpretation of the data, and iii) writing and submission of the article for publication.