Journal article
Overexpression of Anti-Müllerian hormone disrupts gonadal sex differentiation, blocks sex hormone synthesis, and supports cell autonomous sex development in the chicken
LS Lambeth, K Morris, KL Ayers, TG Wise, T O'Neil, S Wilson, Y Cao, AH Sinclair, AD Cutting, TJ Doran, CA Smith
Endocrinology | ENDOCRINE SOC | Published : 2016
DOI: 10.1210/en.2015-1571
Abstract
The primary role of Anti-Müllerian hormone (AMH) during mammalian development is the regression of Müllerian ducts in males. This highly conserved function is retained in birds and is supported by the high levels of AMH expression in developing testes. Mammalian AMH expression is regulated by a combination of transcription factors, the most important being Sry-type high-mobility-group box transcription factor-9 (SOX9). In the chicken embryo, however, AMH mRNA expression precedes that of SOX9, leading to the viewthat AMH may play a more central role in avian testicular development. To define its role in chicken gonadal development, AMH was overexpressed using the RCASBP viral vector. AMH caus..
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Funding Acknowledgements
[ "This research was partly conducted within the Poultry Clinical Research Center, established and supported under the Australian Government's Cooperative Research Centres Program. The Victorian Government's Operational Infrastructure Support Program supports research conducted at the Murdoch Childrens Research Institute.", "This work was funded in part by the Poultry Cooperative Research Centre (held by C.A.S.), an Australian Research Council Future Fellowship (held by C.A.S.), and a Medical Research Council Program grant (held by A.H.S.)." ]