Journal article

Abnormal Brain Areas Common to the Focal Epilepsies: Multivariate Pattern Analysis of fMRI

Mangor Pedersen, Evan K Curwood, David N Vaughan, Amir H Omidvarnia, Graeme D Jackson



Individuals with focal epilepsy have heterogeneous sites of seizure origin. However, there may be brain regions that are common to most cases of intractable focal epilepsy. In this study, we aim to identify these using multivariate analysis of task-free functional MRI. Fourteen subjects with extratemporal focal epilepsy and 14 healthy controls were included in the study. Task-free functional MRI data were used to calculate voxel-wise regional connectivity with regional homogeneity (ReHo) and weighted degree centrality (DCw), in addition to regional activity using fraction of amplitude of low-frequency fluctuations (fALFF). Multivariate pattern analysis was applied to each of these metrics to..

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Awarded by National Health and Medical Research Council (NHMRC) of Australia

Awarded by NHMRC practitioner fellowship

Funding Acknowledgements

The authors acknowledge Mira Semmelroch for assistance with the patient data. This study was supported by the National Health and Medical Research Council (NHMRC) of Australia (program grant 628952). The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and, in particular, the funding from the Operational Infrastructure Support Grant. G.J. is supported by an NHMRC practitioner fellowship (1060312). M.P. is supported by The University of Melbourne scholarships (MIRS & MIFRS). D.V. is supported by an NHMRC postgraduate scholarship.