Journal article
Cross-Study Comparison reveals common genomic, network, and functional signatures of desiccation resistance in drosophila melanogaster
M Telonis-Scott, CM Sgró, AA Hoffmann, PC Griffin
Molecular Biology and Evolution | Published : 2016
Abstract
Repeated attempts to map the genomic basis of complex traits often yield different outcomes because of the influence of genetic background, gene-by-environment interactions, and/or statistical limitations. However, where repeatability is low at the level of individual genes, overlap often occurs in gene ontology categories, genetic pathways, and interaction networks. Here we report on the genomic overlap for natural desiccation resistance from a Pool-genome-wide association study experiment and a selection experiment in flies collected from the same region in southeastern Australia in different years.We identified over 600 single nucleotide polymorphisms associated with desiccation resistanc..
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Awarded by DECRA fellowship
Funding Acknowledgements
We thank Robert Good for the fly sampling, and Jennifer Shirriffs and Lea and Alan Rako for outstanding assistance with laboratory culture and substantial desiccation assays. We are grateful to Melissa Davis for advice on network building and comparison approaches, and to five anonymous reviewers whose comments improved the manuscript. This work was supported by a DECRA fellowship DE120102575 and Monash University Technology voucher scheme to M.T.S., an ARC Future Fellowship and Discovery Grants to C.M.S., an ARC Laureate Fellowship to A.A.H., and a Science and Industry Endowment Fund grant to C.M.S. and A.A.H.