Journal article
Critical B-lymphoid cell intrinsic role of endogenous MCL-1 in c-MYC-induced lymphomagenesis
S Grabow, GL Kelly, ARD Delbridge, PN Kelly, P Bouillet, JM Adams, A Strasser
Cell Death and Disease | Published : 2016
Abstract
Evasion of apoptosis is critical for tumorigenesis, and sustained survival of nascent neoplastic cells may depend upon the endogenous levels of pro-survival BCL-2 family members. Indeed, previous studies using gene-targeted mice revealed that BCL-XL, but surprisingly not BCL-2, is critical for the development of c-MYC-induced pre-B/B lymphomas. However, it remains unclear whether another pro-survival BCL-2 relative contributes to their development. MCL-1 is an intriguing candidate, because it is required for cell survival during early B-lymphocyte differentiation. It is expressed abnormally high in several types of human B-cell lymphomas and is implicated in their resistance to chemotherapy...
View full abstractGrants
Awarded by National Science Foundation
Funding Acknowledgements
We thank Prof S Cory for mice; Dr. LA O'Reilly for discussions; L Reid, J Mansheim, N Iannarella, S Allan, C D'Alessandro and G Siciliano for expert animal care; B Helbert for genotyping; J Corbin for automated blood analysis. This work was supported by grants and fellowships from the Cancer Council of Victoria (SG, ARDD), Leukaemia Foundation Australia (SG), the Lady Tata Memorial Trust (SG), Cure Brain Cancer Australia (AS), the National Health and Medical Research Council (Program Grant #1016701, NHMRC Australia Fellowship 1020363 to AS, Project Grant #1086291 to GLK), the Leukemia and Lymphoma Society (SOCR Grant #7001-03 to AS), Kay Kendall Leukemia Fund Intermediate Fellowship KKL331 (GLK), Cancer Council Victoria Grant-In-Aid #1086157 (GLK), Melbourne International Research and the Melbourne International Fee Remission Scholarship (University of Melbourne, SG) and Cancer Therapeutics CRC Top-up Scholarship (SG, ARDD). The estate of Anthony (Toni) Redstone OAM, University of Melbourne International Research and International Fee Remission Scholarships (SG), Australian Postgraduate Award (ARDD), and the operational infrastructure grants through the Australian Government IRIISS and the Victorian State Government OIS.