Change in weight and waist circumference and risk of colorectal cancer: results from the Melbourne Collaborative Cohort Study
A Karahalios, J Simpson, L Baglietto, RJ MacInnis, AM Hodge, GG Giles, DR English
BMC Cancer | BioMed Central | Published : 2016
BACKGROUND: Studies reporting the association between change in weight or body mass index during midlife and risk of colorectal cancer have found inconsistent results, and only one study to date has reported the association between change in waist circumference (a measure of central adiposity) and risk of colorectal cancer. METHODS: We investigated the association between risk of colorectal cancer and changes in directly measured waist circumference and weight from baseline (1990-1994) to wave 2 (2003-2007). Cox regression, with age as the time metric and follow-up starting at wave 2, adjusted for covariates selected from a causal model, was used to estimate the Hazard Ratios (HRs) and 95..View full abstract
Awarded by VicHealth
Awarded by National Health & Medical Research Council (NHMRC)
Awarded by Australian National Health and Medical Research Council (NHMRC)
Recruitment of the Melbourne Collaborative Cohort Study was funded by VicHealth and Cancer Council Victoria. This work was supported by National Health & Medical Research Council (NHMRC) [grant numbers 209057, 251533, 504711, 1035261] and Vic-Health (grant number 1998-0406). Further infrastructure support was provided Cancer Council Victoria, and funding was received from the Australian Brewers' Foundation to collect alcohol data at wave 2. Cases and their vital status were ascertained through the Victorian Cancer Registry (VCR) and the Australian Institute of Health and Welfare (AIHW), including the National Death Index and the Australian Cancer Database. AK was funded by an Australian Postgraduate Award. LB is supported by a Marie Curie International Incoming Fellowship within the 7th European Community Framework Programme. JAS is supported by an Australian National Health and Medical Research Council (NHMRC) Senior Research Fellowship 1104975.