Review article: sarcopenia in cirrhosis - aetiology, implications and potential therapeutic interventions
M Sinclair, PJ Gow, M Grossmann, PW Angus
ALIMENTARY PHARMACOLOGY & THERAPEUTICS | WILEY | Published : 2016
BACKGROUND: Sarcopenia (loss of muscle mass) is common in cirrhosis and is associated with poor outcomes. Current teaching recommends the use of protein supplementation and exercise, however, this fails to address many other factors which contribute to muscle loss in this setting. AIMS: To summarise existing knowledge regarding the aetiology of sarcopenia in cirrhosis, diagnostic modalities and the clinical significance of this condition. In addition to discuss recent research findings that may allow the development of more effective treatments. METHODS: We conducted a Medline and PubMed search using the search terms 'sarcopenia', 'muscle', 'body composition', 'cirrhosis', 'liver' and 'malnu..View full abstract
There are no conflicts of interest to report in the writing of this manuscript. An Australian Postgraduate Award from the University of Melbourne to Marie Sinclair assisted in the production of this work.