Journal article

Axonal activity-dependent myelination in development: Insights for myelin repair

Stanislaw Mitew, Yao Lulu Xing, Tobias D Merson



Recent advances in transgenic tools have allowed us to peek into the earliest stages of vertebrate development to study axon-glial communication in the control of peri-natal myelination. The emerging role of neuronal activity in regulating oligodendrocyte progenitor cell behavior during developmental myelination has opened up an exciting possibility-a role for neuronal activity in the early stages of remyelination. Recent work from our laboratory and others has also shown that contrary to previously established dogma in the field, complete remyelination up to pre-demyelination levels can be achieved in mouse models of MS by oligodendrogenic neural precursor cells that derive from the adult s..

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University of Melbourne Researchers


Awarded by Australian Research Council Future Fellowship

Awarded by National Health and Medical Research Council

Funding Acknowledgements

S.M. is supported by a Multiple Sclerosis Research Australia Postdoctoral Fellowship, Y.L.X. is supported by a Strategic Research Australian Postgraduate Award (Stem Cells Australia), T.D.M. is supported by an Australian Research Council Future Fellowship (FT150100207), the National Health and Medical Research Council (APP1066199) and Stem Cells Australia-the Australian Research Council Special Research Initiative in Stem Cell Science. Charity Works for MS and the Victorian Operational Infrastructure Support Program provided additional support. The authors declare no competing financial interests.