Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials

Mayank Goyal; Bijoy K Menon; Wim H van Zwam; Diederik WJ Dippel; Peter J Mitchell; Andrew M Demchuk; Antoni Davalos; Charles BLM Majoie; Aad van der Lugt; Maria A de Miquel; Geoff Rey A Donnan; Yvo BWEM Roos; Alain Bonafe; Reza Jahan; Hans-Christoph Diener; Lucie A van den Berg; Elad I Levy; Olvert A Berkhemer; Vitor M Pereira; Jeremy Rempel; Monica Millan; Stephen M Davis; Daniel Roy; John Thornton; Luis San Roman; Marc Ribo; Debbie Beumer; Bruce Stouch; Scott Brown; Bruce CV Campbell; Robert J van Oostenbrugge; Jeff Rey L Saver; Michael D Hill; Tudor G Jovin

Journal article

Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials

Mayank Goyal, Bijoy K Menon, Wim H van Zwam, Diederik WJ Dippel, Peter J Mitchell, Andrew M Demchuk, Antoni Davalos, Charles BLM Majoie, Aad van der Lugt, Maria A de Miquel, Geoff Rey A Donnan, Yvo BWEM Roos, Alain Bonafe, Reza Jahan, Hans-Christoph Diener, Lucie A van den Berg, Elad I Levy, Olvert A Berkhemer, Vitor M Pereira, Jeremy Rempel Show all

LANCET | ELSEVIER SCIENCE INC | Published : 2016

DOI: 10.1016/S0140-6736(16)00163-X

Abstract

BACKGROUND: In 2015, five randomised trials showed efficacy of endovascular thrombectomy over standard medical care in patients with acute ischaemic stroke caused by occlusion of arteries of the proximal anterior circulation. In this meta-analysis we, the trial investigators, aimed to pool individual patient data from these trials to address remaining questions about whether the therapy is efficacious across the diverse populations included. METHODS: We formed the HERMES collaboration to pool patient-level data from five trials (MR CLEAN, ESCAPE, REVASCAT, SWIFT PRIME, and EXTEND IA) done between December, 2010, and December, 2014. In these trials, patients with acute ischaemic stroke caused..

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