Journal article

Changes in Quality of Life Associated with Complications of Diabetes: Results from the ADVANCE Study

Alison Hayes, Hisatomi Arima, Mark Woodward, John Chalmers, Neil Poulter, Pavel Hamet, Philip Clarke

VALUE IN HEALTH | ELSEVIER SCIENCE INC | Published : 2016

Abstract

OBJECTIVE: To measure the impact of complications on summary measures of health-related quality of life among people with type 2 diabetes. METHODS: Patients participating in the Action in Diabetes and Vascular Disease:Preterax and Diamicron MR Controlled Evaluation (ADVANCE) trial were administered a health-related quality-of-life questionnaire, the three-level EuroQol five-dimensional questionnaire (EQ-5D-3L), on four occasions over a 5-year period. We used two-way fixed-effects longitudinal regression models to investigate the impact of incident diabetes complications (stroke, heart failure, myocardial infarction, ischemic heart disease, renal failure, blindness, and amputation) on EQ-5D-3..

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