Journal article

Functional advantage of educated KIR2DL1( ) natural killer cells for anti-HIV-1 antibody-dependent activation

SL Gooneratne, RJ Center, SJ Kent, MS Parsons

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | WILEY-BLACKWELL | Published : 2016

Abstract

Evidence from the RV144 HIV-1 vaccine trial implicates anti-HIV-1 antibody-dependent cellular cytotoxicity (ADCC) in vaccine-conferred protection from infection. Among effector cells that mediate ADCC are natural killer (NK) cells. The ability of NK cells to be activated in an antibody-dependent manner is reliant upon several factors. In general, NK cell-mediated antibody-dependent activation is most robust in terminally differentiated CD57(+) NK cells, as well as NK cells educated through ontological interactions between inhibitory killer immunoglobulin-like receptors (KIR) and their major histocompatibility complex class I [MHC-I or human leucocyte antigen (HLA-I)] ligands. With regard to ..

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University of Melbourne Researchers