Journal article

The Outcomes and Patterns of Treatment Failure After Surgery for Locally Recurrent Rectal Cancer

Craig A Harris, Michael J Solomon, Alexander G Heriot, Peter M Sagar, Paris P Tekkis, Liane Dixon, Rebecca Pascoe, Bruce R Dobbs, Chris M Frampton, Deena P Harji, Christos Kontovounisios, Kirk K Austin, Cherry E Koh, Peter J Lee, Andrew C Lynch, Satish K Warrier, Frank A Frizelle

ANNALS OF SURGERY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2016

Abstract

OBJECTIVE: To assess the outcomes and patterns of treatment failure of patients who underwent pelvic exenteration surgery for recurrent rectal cancer. BACKGROUND: Despite advances in the management of rectal cancer, local recurrence still occurs. For appropriately selected patients, pelvic exenteration surgery can achieve long-term disease control. METHODS: Prospectively maintained databases of 5 high volume institutions for pelvic exenteration surgery were reviewed and data combined. We assessed the combined endpoints of overall 5-year survival, cancer-specific 5-year mortality, local recurrence, and the development of metastatic disease. RESULTS: Five hundred thirty-three patients who had ..

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