Journal article
Clinicopathological characteristics associated with BRAFK601E and BRAFL597 mutations in melanoma
M Voskoboynik, V Mar, S Mailer, A Colebatch, A Fennessy, A Logan, C Hewitt, J Cebon, J Kelly, G Mcarthur
Pigment Cell and Melanoma Research | Published : 2016
DOI: 10.1111/pcmr.12450
Abstract
BRAF mutations at codons L597 and K601 occur uncommonly in melanoma. Clinical and pathological associations of these mutations were investigated in a cohort of 1119 patients with known BRAF mutation status. A BRAF mutation was identified in 435 patients; Mutations at L597 and the K601E mutation were seen in 3.4 and 3.2% of these, respectively. K601E melanomas tended to occur in male patients, a median age of 58 yr, were generally found on the trunk (64%) and uncommonly associated with chronically sun-damaged (CSD) skin. BRAF L597 melanomas occurred in older patients (median 66 yr), but were associated with CSD skin (extremities or head and neck location - 73.3%, P = 0.001). Twenty-three perc..
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Funding Acknowledgements
The authors wish to acknowledge Danilo Acosta, Elva Shi, Timmy Chan, Victoria Michael, Amanda Lucas, Kateh Namdarian, Hazel Phillimore, Su-Ping Chang, Ravikiran Vedururu and Anthony Bell for their assistance with this project. We acknowledge the Melanoma Research Alliance (MRA), the Melbourne Melanoma Project (MMP), La Trobe University and the Victorian State Government Operational Infrastructure Support Program for partial funding of this project.