Journal article

Parechovirus Encephalitis and Neurodevelopmental Outcomes

Philip N Britton, Russell C Dale, Michael D Nissen, Nigel Crawford, Elizabeth Elliott, Kristine Macartney, Gulam Khandaker, Robert Booy, Cheryl A Jones



OBJECTIVE: We aimed to describe the clinical features and outcome of human parechovirus (HPeV) encephalitis cases identified by the Australian Childhood Encephalitis (ACE) study. METHODS: Infants with suspected encephalitis were prospectively identified in 5 hospitals through the (ACE) study. Cases of confirmed HPeV infection had comprehensive demographic, clinical, laboratory, imaging, and outcome at discharge data reviewed by an expert panel and were categorized by using predetermined case definitions. Twelve months after discharge, neurodevelopment was assessed by using the Ages and Stages Questionnaire (ASQ). RESULTS: We identified thirteen cases of suspected encephalitis with HPeV infec..

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Awarded by NHMRC postgraduate scholarship

Awarded by NHMRC Practitioner Fellowship

Awarded by NHMRC Health Early Career Fellowship

Funding Acknowledgements

The Australian Childhood Encephalitis study is funded by grants from the Australian Department of Health (Surveillance branch) and the National Health and Medical Research Council (NHMRC) of Australia Centre for Research Excellence in Critical Infections; both to Dr Jones and Dr Booy. Dr Britton is supported by an NHMRC postgraduate scholarship (1074547), the Royal Australasian College of Physicians (RACP) NHMRC Award for Excellence, and Norah Therese-Hayes/Sydney Medical School Dean's paediatric infectious diseases fellowship. Dr Elliott is supported by an NHMRC Practitioner Fellowship (1021480). Dr Dale is supported by an NHMRC Practitioner Fellowship (1059157). Dr Khandaker is supported by an NHMRC Health Early Career Fellowship (1054414).