Polygenic phenotypic plasticity moderates the effects of severe childhood abuse on depressive symptom severity in adulthood: A 5-year prospective cohort study

CA Bousman; JM Gunn; M Potiriadis; IP Everall

Journal article

Polygenic phenotypic plasticity moderates the effects of severe childhood abuse on depressive symptom severity in adulthood: A 5-year prospective cohort study

CA Bousman, JM Gunn, M Potiriadis, IP Everall

World Journal of Biological Psychiatry | Published : 2017

DOI: 10.3109/15622975.2016.1153710

Abstract

Objective To test the phenotypic plasticity framework using a polygenic approach in a prospective depression cohort of primary care attendees with and without histories of severe childhood abuse. Methods Depressive symptoms were assessed at baseline and annually for 5 years post-baseline using the Primary Care Evaluation of Mental Disorders Patient Health Questionnaire-9 (PHQ-9) among 288 adult primary care attendees. Twelve polymorphisms in nine genes were genotyped and polygenic phenotypic plasticity allelic load (PAL) calculated. Linear mixed models assessed differences in depressive symptom severity over the 5-year follow-up period by PAL and history of severe childhood abuse. Results A ..

View full abstract

University of Melbourne Researchers

Jane Gunn Author

Related Projects (4)

Diagnosis, Management and Outcomes of Depression in Primary care (DIAMOND) a longitudinal study

Depression is the single largest cause of disability for people in Australia. It is mainly managed in general practice, yet many people expe..

The diamond cohort study - long term outcomes of depressive symptoms in primary care

The diamond study follows what happens to almost 800 people with depressive symptoms whom attend general practice for care over 5 years of t..

The diamond cohort study- examining depressive symptoms in primary care

Depression is the single largest cause of disability for people in Australia. It is mainly managed in general practice-primary care, yet man..

The diamond cohort study - long term outcomes of depressive

Diamond began in 2005 to follow over 500 people with depressive symptoms to document and describe the nature and course of depression and it..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

The named authors submit this publication on behalf of the diamond study investigators which include: Professor Jane Gunn, Professor Helen Herrman, Professor Mike Kyrios, A/Professor Kelsey Hegarty, Professor Christopher Dowrick, Dr Gail Gilchrist, Associate Professor Grant Blashki, Professor Dimity Pond, Ms Patty Chondros, Dr Renata Kokanovic and Dr Victoria Palmer. The diamond project is funded by the National Health and Medical Research Council (ID: 299869, 454463, 566511 and 1002908) and the Victorian Centre for Excellence in Depression and Related Disorders, an initiative between beyondblue and the State Government of Victoria. The collection of DNA and genotyping was funded by the LEW Carty Chartable Fund (ID: 7284). No funding body had a role in the study design; the collection, analysis, and interpretation of data; or the writing of the manuscript for publication. C.B. had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. We acknowledge the 30 dedicated GPs, their patients and practise staff for making this research possible. We thank the cohort participants for their ongoing involvement in the study. We also thank the diamond project team and associate investigators involved in the study: Dr Lena Sanci, Ms Catherine Mihalopoulos, Ms Maria Potiriadis, Ms Konstancja Densley, Ms Aves Middleton, Ms Melanie Charity and the casual research staff.