Journal article
Real-world cost-effectiveness of pharmacogenetic screening for epilepsy treatment
Z Chen, D Liew, P Kwan
Neurology | Published : 2016
Abstract
Objective: To assess the cost-effectiveness of the HLA-B∗15:02 screening policy for the treatment of epilepsy in Hong Kong. Methods: From all public hospitals and clinics in Hong Kong, 13,231 patients with epilepsy who started their first antiepileptic drug (AED) between September 16, 2005, and September 15, 2011 (3 years before and 3 years after policy implementation on September 16, 2015), were identified retrospectively. A decision tree model was constructed to incorporate the real-world data on AED prescription patterns, incidences of AED-induced Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), costs of AED treatments, SJS/TEN treatment, and HLA-B∗15:02 testing, and quali..
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Funding Acknowledgements
Z. Chen reports no disclosures relevant to the manuscript. D. Liew has received research grants from the National Health and Medical Research Council of Australia, the Australian Research Council, and the National Heart Foundation of Australia. He/his institution has also received speaker or consultancy fees and/or research grants from Pfizer, AbbVie, Sanofi, AstraZeneca, GlaxoSmithKline, and Amgen. P. Kwan has received research grants from the National Health and Medical Research Council of Australia, the Australian Research Council, the US NIH, Hong Kong Research Grants Council, Innovation and Technology Fund, Health and Health Services Research Fund, and Health and Medical Research Fund. He/his institution also received speaker or consultancy fees and/or research grants from Eisai, GlaxoSmithKline, Johnson & Johnson, Pfizer, and UCB Pharma. Go to Neurology.org for full disclosures.