Journal article

Micro-CT analysis of the anatomical characteristics of the stapedial annular ligament

Aydin Mohammadi, Nicholas Jufas, Philip Sale, Kirsti Lee, Nirmal Patel, Stephen O'Leary

ANATOMICAL SCIENCE INTERNATIONAL | SPRINGER | Published : 2017

Abstract

The oval window region has recently been identified as a potential route for drug diffusion into the inner ear. Locally applied gadolinium and trimethylphenylammonium (TMPA) have been shown to directly diffuse into the vestibule through the oval window region. Given the potential importance of the oval window region in the diffusion of substances into the inner ear, this work aimed to use micro-CT to obtain a data set of anatomical characteristics of the annular ligament of the stapes in the human temporal bone, a region thus far poorly studied. Twenty-one temporal bones were micro-dissected to preserve the otic capsule and allow perfusion of fixative stains into the inner ear. The specimens..

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University of Melbourne Researchers