Changes in morphology of retinal ganglion cells with eccentricity in retinal degeneration
EE Anderson, U Greferath, EL Fletcher
CELL AND TISSUE RESEARCH | SPRINGER | Published : 2016
Ganglion cells are the output neurons of the retina and are known to remodel during the subtle plasticity changes that occur following the death of photoreceptors in inherited retinal degeneration. We examine the influence of retinal eccentricity on anatomical remodelling and ganglion cell morphology well after photoreceptor loss. Rd1 mice that have a mutation in the β subunit of phosphodiesterase 6 were used as a model of retinal degeneration and gross remodelling events were examined by processing serial sections for immunocytochemistry. Retinal wholemounts from rd1-Thy1 and control Thy1 mice that contained a fluorescent protein labelling a subset of ganglion cells were processed for immun..View full abstract
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Awarded by NHMRC project grant
This work was supported by an NHMRC project grant (APP1021042), by Retina Australia and by the Australian Research Council through its Special Research Initiative in Bionic Vision Science and Technology grant to Bionic Vision Australia.