Journal article

Dermal Matrices and Bioengineered Skin Substitutes: A Critical Review of Current Options

Heidi Debels, Moustapha Hamdi, Keren Abberton, Wayne Morrison

PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN | LIPPINCOTT WILLIAMS & WILKINS | Published : 2015

Abstract

BACKGROUND: Over recent decades, scientists and surgeons have collaborated to develop various bioengineered and synthetic products as an alternative to skin grafts. Despite the numerous articles and reviews written about dermal skin substitutes, there is no general consensus. METHODS: This article reviews dermal skin scaffolds used in clinical applications and experimental settings. For scaffold evaluation, we focused on clinical and/or histological results, and conclusions are listed. Explanations for general trends were sought based on existing knowledge about tissue engineering principles and wound healing mechanisms. RESULTS: Decellularized dermis seems to remain the best option with no ..

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