Journal article
Alcohol consumption and breast cancer risk by estrogen receptor status: In a pooled analysis of 20 studies
S Jung, M Wang, K Anderson, L Baglietto, L Bergkvist, L Bernstein, PA van den Brandt, L Brinton, JE Buring, A Heather Eliassen, R Falk, SM Gapstur, GG Giles, G Goodman, J Hoffman-Bolton, PL Horn-Ross, M Inoue, LN Kolonel, V Krogh, M Lof Show all
International Journal of Epidemiology | Published : 2016
DOI: 10.1093/ije/dyv156
Abstract
Background: Breast cancer aetiology may differ by estrogen receptor (ER) status. Associations of alcohol and folate intakes with risk of breast cancer defined by ER status were examined in pooled analyses of the primary data from 20 cohorts. Methods: During a maximum of 6-18 years of follow-up of 1 089 273 women, 21 624 ER+ and 5113 ER- breast cancers were identified. Study-specific multivariable relative risks (RRs) were calculated using Cox proportional hazards regression models and then combined using a random-effects model. Results: Alcohol consumption was positively associated with risk of ER+ and ER- breast cancer. The pooled multivariable RRs (95% confidence intervals) comparing≥30 g/..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by a National Institute of Health grant CA55075 and a Breast Cancer Research Foundation grant.