Journal article

Emotion recognition and theory of mind are related to gray matter volume of the prefrontal cortex in schizophrenia

Arija Maat, Neeltje EM van Haren, Cali F Bartholomeuz, Rene S Kahn, Wiepke Cahn



Investigations of social cognition in schizophrenia have demonstrated consistent impairments compared to healthy controls. Functional imaging studies in schizophrenia patients and healthy controls have revealed that social cognitive processing depends critically on the amygdala and the prefrontal cortex (PFC). However, the relationship between social cognition and structural brain abnormalities in these regions in schizophrenia patients is less well understood. Measures of facial emotion recognition and theory of mind (ToM), two key social cognitive abilities, as well as face perception and IQ, were assessed in 166 patients with schizophrenia and 134 healthy controls. MRI brain scans were ac..

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Awarded by Geestkracht programme of the Dutch Health Research Council

Funding Acknowledgements

The infrastructure for the GROUP study was funded through the Geestkracht programme of the Dutch Health Research Council (ZON-MW, Grant no. 10-000-1002), and matching funds from participating Pharmaceutical Companies (Lundbeck, AstraZeneca, Eli Lilly, Janssen Cilag) and Universities and Mental Health Care Organizations (Amsterdam: Academic Psychiatric Center of the Academic Medical Center and the mental health institutions: GGZ Ingeest, Arkin, Dijk en Duin, Rivierduinen, Erasmus Medical Center, GGZ Noord Holland Noord. Maastricht: Maastricht University Medical Center and the mental health institutions: GGZ Eindhoven, GGZ Midden-Brabant, GGZ Oost-Brabant, GGZ Noord-Midden Limburg, Mondriaan Zorggroep, Prins Clauscentrum Sittard, RIAGG Roermond, Universitair Centrum Sint-Jozef Kortenberg, CAPRI University of Antwerp, PC Ziekeren Sint-Truiden, PZ Sancta Maria Sint-Truiden, GGZ Overpelt, OPZ Rekem. Groningen: University Medical Center Groningen and the mental health institutions: Lentis, GGZ Friesland, GGZ Drenthe, Dimence, Mediant, GGZ De Grote Rivieren and Parnassia psycho-medical centre (The Hague). Utrecht: University Medical Center Utrecht and the mental health institutions Altrecht, Symfora, Meerkanten, Riagg Amersfoort and Delta).